编号：CDUT-2022-27

标题：Colorimetric and fluorescent detection of glutathione over cysteine and homocysteine with red-emitting N-doped carbon dots

入藏号：WOS:000562371500003

中国科学院文献情报中心期刊分区：工程技术1区/TOP

本校作者：贾若男

来源出版物：SENSORS AND ACTUATORS B-CHEMICAL 卷:321 文献号:128506

出版年：2020

第一地址：成都理工大学

关键词：Glutathione；Carbon dots；Selective detection；Colorimetric detection

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摘要：Glutathione (GSH) is an important biothiol in biological systems and serves as a significant biomarker for thehealth of humans. Herein, red-emitting carbon dots (p-CDs) prepared by a simple one-step solvothermal processcan exclusively, rapidly and sensitively respond to GSH owing to the high content of pyridinic N. Upon additionof GSH, p-CDs instantly give a significant color change from orange to bluish-purple. The absorbance ratio of576 nm to 486 nm is linearly proportional to the logarithmic concentration of GSH in a wide range of12.5−800 μM, which is the level of cellular GSH. Meanwhile, the fluorescence of p-CDs quenches obviously. TheLOD of p-CDs towards GSH in fluorescence mode is 0.7 μM. Moreover, p-CDs have no response to Cys, Hcy,amino acids and ions existing in biological systems. Such a promising responsiveness offers a great opportunityto accurately, sensitively and selectively detect GSH by colorimetric and fluorescent dual modes. In addition,cellulose/p-CDs hydrogels and p-CDs-based test papers have been fabricated to successfully detect GSH accordingto the color-change and fluorescence quenching. The biocompatible, environment-friendly and disposablecellulose/p-CDs materials readily provide a simple and visual strategy to detect GSH levels in the biomedicalfields.

文章链接地址：https://www.sciencedirect.com/science/article/pii/S0925400520308522