编号：CDUT-2021-61

标题：Biomimetic scaffolds with programmable pore structures for minimum invasive bone repair

入藏号： WOS:000701961100001

中国科学院文献情报中心期刊分区： 工程技术2区/TOP（2021年基础版）

本校作者：王立；曾西洋；颜贵龙；陈小虎；罗昆；周世一；张佩聪；李俊峰

来源出版物：NANOSCALE 卷: 13 期: 39 页: 16680-16689

出版年： 2021

第一地址：成都理工大学

关键词：可编程孔结构，聚氨酯，羟基磷灰石，生物相容性，骨组织工程

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摘要：Due to the complexity of surgery for large-area bone injuries, implanting a large volume of materials into the injury site remains a big challenge in orthopedics. To solve this difficulty, in this study, a series of biomimetic hydroxyapatite/shape-memory composite scaffolds were designed and synthesized with programmable pore structures, based on poly(epsilon-caprolactone) (PCL), polytetrahydrofuran (PTMG) and the osteoconductive hydroxyapatite (HA). The obtained scaffolds presented various pore structures, high connectivity, tunable mechanical properties, and excellent shape memory performance. Moreover, the mineralization activity of the developed scaffolds could enhance the formation of hydroxyapatite and they showed good biocompatibility in vitro. The in vivo experiments show that scaffolds could promote the formation of new bone in critical size cranial defects. The programmable porous scaffold biomaterials exhibited potential application promise in bone regeneration.

摘要文章链接地址：https://pubs.rsc.org/en/content/articlelanding/2021/NR/D1NR04124J